Self-assembled porphyrinoids: one-component nanostructured photomedicine

Photodynamic therapy (PDT) is becoming a promising way to treat various kinds of cancers, with few side effects. Porphyrinoids are the most relevant photosensitizers (PS) in PDT, because they present high extinction coefficients, biocompatibility, and excellent photochemical behavior. To maximize therapeutic effects, polymer-PS conjugates, and PS-loaded nanoparticles have been developed, with insights in improving tumor delivery. However, some drawbacks such as non-biodegradability, multistep fabrication, and low reagent loadings limit their clinical application. A novel strategy, noted by some authors as the “one-for-all” approach, is emerging to circumvent the use of additional delivery agents. This approach relies on the self-assembly of amphiphilic PS to fabricate nanostructures with improved transport properties. In this review we focus on different rational designs of porphyrinoid PS to achieve some of the following attributes in nanoassembly: i) selective uptake, through the incorporation of recognizable biological vectors; ii) responsiveness to stimuli; iii) combination of imaging and therapeutic functions; and iv) multimodal therapy, including photothermal or chemotherapy abilitiesThe research team has been supported by MINECO (CTQ2017- 85393-P) and ERA-NET/MINECO EuroNanoMed2017-191/PCIN 2017-042. IMDEA Nanociencia acknowledges support from the ‘Severo Ochoa’ Program for Centers of Excellence in R&D (MINECO, Grant SEV-2016-0686

Recuperación de Información sobre Patentes: Comparación de Recuperación de Información Web Entre Patentscope y Google Patents

The goal is to present the main free and open access search engines such as PATENTSCOPE and Google Patents. It also seeks to verify the information retrieval system, which seeks to transform the user's information needs into a list or collection of documents whose content satisfies that need. We present the comparison of both verifying each one independently and then, a summary table. Finally, it is concluded that the constant search for inventions can make the difference between the positions of competences between global companies; It is for this reason that patents prove to be a source of reliable information on the subjects of interest of the people or companies. Pantestscope and Google Patents allows you to download as much data as a table for future analysis of the information. Keywords: Information retrieval, Patents, Patentscope, Google Patents, We

Real World Data en la Sanidad Española

In recent years, thanks to the progress of electronics and computing, it is possible to process a large volume of clinical data. As a result of this scenario, real world data (RWD) are gaining enormous relevance. RWD are the data, whose origin is the usual clinical practice, used to make medical decisions about drugs or medical practice. This research is aimed to study the current situation of RWD in Spain. To achieve this objective, we have assessed the data sources on which these are fed. We have also analyzed the main publications based on RWD. Our findings are: firstly, both records and databases as well as medical histories have a high level of computerization and have also a great deal of information to be used for research; and secondly, the scientific studies carried out are of a great quality, but society is not aware of the importance RWD have and there is discoordination between the Autonomies and the Government. Keywords: RWD, clinical data, medical decisions, practical decisions, medical historie

Metallo-organic ensembles of tritopic subphthalocyanine ligands

"This is the peer reviewed version of the following article: M. Ángel Revuelta-Maza, Ettore Fazio, Gema de la Torre and Tomás Torres, Metallo-organic ensembles of tritopic subphthalocyanine ligands, Journal of Porphyrins and PhthalocyaninesVol. 21, No. 12, pp. 782-789 (2017), which has been published in final form at https://doi.org/10.1142/S1088424617500882I. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use Self-Archived Versions"Organic building blocks containing amines and aldehydes can be used for the preparation of complex metallo-organic structures, such as M2L3 triple helicates or face-capped M4L4 tetrahedral cages, through the formation of both dynamic covalent and coordinative linkages during the self-Assembly process. Herein we describe how the subcomponent self-Assembly method can be succesfully applied over a triamine-functionalized subphthalocyanine (SubPc) ligand to build metallo-supramolecular helicates. Two isomeric SubPcs (C1-SubPc1 and C3-SubPc1) have been prepared from the corresponding C1-SubPcI3 and C3-SubPcI3 precursors under optimized Suzuki conditions. We selected the tritopic C3-SubPc1 derivative as ligand for the subcomponent self-Assembly experiments, which involved the reaction with 2-formylpyridine and different Fe(II) salts. The self-Assembly process was mainly studied by mass spectrometry (ESI direct injection techniques), and in all the conditions applied, we could observe the formation of helicate-Type Fe2SubPc3 structures and/or Fe2SubPc4 species, which can be considered as open precursors of Fe4SubPc4 tetrahedral cages. © 2017 World Scientific Publishing Company.Financial support from Comunidad de Madrid, Spain (S2013/MIT- 2841, FOTOCARBON), and Spanish MICINN (CTQ2014-52869-P) is acknowledged

Estudio de la Seguridad en Redes de Sensores Corporales aplicadas al Ámbito Sanitario

Nowadays, the technology has become necessary in daily aspects of everyday life, included healthcare and healthy lifestyle. Thus, in the last years has taken place an important development of Body Sensor Networks (BSN) to let a continuous monitoring. Security is becoming increasingly important in all areas related to Information Technology, and becomes even more important when patient’s health is involved. Confiability and privacy are necessary requirements for patients to feel secure with the sensors, but the reliability is necessary too, because if all measured data are lost or damage before reaching their destination, it cannot be made an adequate monitor or make the best diagnosis. The aim of this work is to provide a review of the security for BSN applied to the healthcare, in order to enable the development of applications to improve the patient's diagnosis and treatment with chronic diseases.Keywords: BSN, healthcare,confiability, reliability, chronic diseases

In-situ hydration studies of ye’elemite at early ages for understanding eco-cement performances'

Póster; ALBA User Meeting and VI AUSE Conferenc

Pushing limits in higher education: inclusion services’ perspectives on supporting students with learning disabilities in Spanish universities

The unprecedented growth of universities in recent years has meant that there are more students with learning disabilities attending courses. Consequently, universities have had to adapt, improve and create new resources to ensure greater inclusivity. These resources, their design, and development are managed by inclusion support services, aiming to the full inclusion of students with disabilities and the promotion of community awareness. This article aims to shed light on the current role of inclusion services in supporting students with learning disabilities, and the link these services have with the different university stakeholders, using a thematic analysis from the experiences of this services staff in eight Spanish universities. The results show that: i) there is no uniformity in the support services; and ii) more resources and work are needed to ensure increased inclusion and awareness. The discussion and conclusions drawn highlight the trends, challenges, and opportunities for universities improving their inclusion.Postprint (author's final draft

Uso de la cáscara de maní en paneles prefabricados para viviendas de interés social en Manabí.

The present work, as a pre-feasibility investigation, studies the possibility of implementing a system of non-bearing panels as masonry, inserting in its elaboration the agricultural residue "peanut shell" as filler material in its mortar within a defined spatial distribution and approved as housing of social interest according to the Ecuadorian normative organisms without changing its structural operation. This with the dual purpose of testing the feasibility of industrialization in low-income housing with execution on site, local labor force and at the same time promoting the criteria of ecological sustainability in the construction of low-income housing with systems that are welcomed by Manabi population. A system of 50x50 panels with double bevel of block type B resistance is presented at a cost of 0.40 cents./unit with replacement of fine snap by peanut shell at 10%. The perception of construction professionals was generally positive after the survey carried out via Google form, as long as the structural behavior of the home is not affected and the finishes are visually maintained.El presente trabajo en carácter de investigación de pre-factibilidad estudia la posibilidad de implementar un sistema de paneles no portantes como mampostería insertando en su elaboración el residuo agrícola “cáscara de maní” como material de relleno en su mortero dentro de una distribución espacial definida y aprobada como vivienda de interés social según los organismos normativos ecuatorianos sin cambiar su funcionamiento estructural. Esto con la doble finalidad de probar la factibilidad de industrialización en viviendas de interés social con ejecución en obra, fuerza de trabajo local y al mismo tiempo potenciar los criterios de sostenibilidad ecológica en la construcción de las viviendas de interés social con sistemas que tengan acogida por la población manabita. Se presenta un sistema de paneles de 50x50 con doble bisel de resistencia del bloque tipo B con un costo de 0.40 ctvs./unidad con reemplazo de chasqui fino por cáscara de maní al 10%. La percepción de lo profesionales de la construcción fue generalmente positiva luego de la encuesta realizada vía formulario de Google form, siempre y cuando no se afecte el comportamiento estructural de la vivienda y los acabados se mantengan visualmente

Clinkering and early age hydration characterization of Belite-Alite Calcium Sulfoaluminate (BACSA) cements

In this work, four BACSA clinkers with different compositions (belite ~ 70-55 wt %, alite ~ 10-15 wt % and ye’elimite ~ 10-15 wt %) were synthesized (at laboratory scale). Lime, gypsum, kaolin and sand were used as raw materials and clinkering temperatures from 1280 to 1300 ºC were studied. Every BACSA clinker was chemically and mineralogically characterized through X-ray fluorescence and laboratory X-ray powder diffraction (LXRPD), the latter in combination with the Rietveld methodology to obtain the full phase assemblage including amorphous contents. The clinker with the targeted composition (belite ~ wt 60 %, alite ~ 13 wt % and ye’elimite ~ 10 wt %) was chosen to perform the scaling-up (5 kg). To do so, the processing parameters (milling time and clinkering conditions) have been optimized. Finally, the hydration of the corresponding BACSA cement pastes (prepared with the scaled-up clinker and gypsum) was studied through rheological measurements (at very early hydration time), calorimetry and impedance spectroscopy (first 24 h), and LXRPD in combination with the Rietveld methodology and G-factor method, at 1 and 7 hydration days to determine degree of hydration.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Rietveld quantitative phase analyses of SRM 2686a: a standard Portland clinker

SRM 2686a is a NIST reference Portland clinker with reported mineralogical analysis from powder diffraction and electron microscopy. This sample is used in ASTM C1365 test method for Rietveld quantitative phase analysis validation procedure. Here, we have analysed SRM 2686a by using three state-of-the-art powder diffraction configurations: i) strictly monochromatic CuKα 1 radiation in flat reflection geometry; ii) strictly monochromatic MoKα 1 radiation in flat transmission geometry; and iii) synchrotron radiation in rotating capillary transmission geometry. The silicate and aluminate enriched residues have also been studied by CuKα 1 powder diffraction. All the powder patterns were analysed by Rietveld method with the best available protocols. The results indicate that belite in SRM 2686a is composed of two polymorphs (- and α’H-) that must be included in the analyses. The use of a unique phase for describing belite (-polymorph) and improper peak shape modelling could explain the problems found for implementing ASTM C1365 in some cement manufacturing plants. Furthermore, all the patterns are deposited as open data access at Zenodo, so interested laboratories can analyse these data to verify their protocols.This work has been supported by Spanish MINECO through BIA2014-57658-C2-2-R, which is co-funded by FEDER, and BIA2014- 57658-C2-1-R. We also thank ALBA synchrotron for providing beam time at BL04-MSPD beamline